What are the advantages and disadvantages of conditional and unconditional methods of MLE?

Conditional methods do not estimate unwanted parameters. Unconditional methods estimate the values of unwanted parameters also. Unconditional formulas can directly be developed with joint probabilities. This cannot be done with conditional probability. If the number of parameters is high relative to the number of instances, then the unconditional method will give biased results. Conditional results will be unbiased in such cases.